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I'm pretty sure GVWR requirements for CDL start at 26,001 pounds.CDL will not be an issue for this little "not for hire" box truck.
Full size 16' box may have the 6cyl which is pretty strong. GVW and usage determines whether or not you need a CDL and vehicle insurance and licensing requirements. Your limited use is that you aren't going to be driving it 8-10hrs a day six days a week. You aren't going into business are you? All vehicles suffer from sitting so plan on some work before putting into service. Some suffer worse than others, some of ours saw pretty limited use during winter and suffered from excessive chassis rust problems, nothing to keep them out of service long, steel brake, fuel lines, that sort of thing.Brian
$5000 was the value 5-10 years ago. NPR great truck. I had a couple. You sure it has a 16' box? they usually came with 14' box unless it was a longer wheel base. It has a turbo 4 really fair diesel mileage(unless it has a chevy v8/auto, under no circumstances buy it with a gas motor, it could get 4-6 miles per gallon) NRR has the same body with a turbo 6 diesel and a longer wheel base allowing 18-22 boxes.
Isuzu was building trucks before WW1. They built trucks before they built cars. Isuzu built a version of the 4wd jeep before any American manufacturer did. They have the experience. In the early 70s I knew of a couple who had an open bed diesel Isuzu of about that size. I drove it. It was simple, just rev it up against the governor and shift to the next gear. It probably would not exceed 60 MPH but it did get better milage than most cars. When I saw the guy about 10 years later it had over 200,000 miles on it and was still going strong. He was a farmer so he probably maintained it well.