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all good suggestions. If i were my wife i'd get an Airhawk and inflate it half way. That's more than recommended but your goal is her comfort. That will work.
I am an avid proponent of sheepskin.Aerostich has applications of various sizes.
My wife and I did a two trip about 10 yrs ago when we were young (late 60's) 7000 miles coast to coast on a Piaggio. The secret for her was bicycling pants. Worked great the whole trip. I recently did a 1700 mile weekend on my Stornello and I never even gave my seat a thought. That's the sign of a good seat. I wouldn't think of spending the money to replace that seat and if nee be bicycling pants are $50
Start on ADVIL before you even throw a leg over. I prefer BC powder, it has caffeine too A couple of airhawks or sheepskin won't hurt either.Oh, and HAVE FUN!