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Since Guzzi engines are stressed members, I would think you would introduce some flex that may, or may not have a negative impact on handling.
I wouldn't recommend... The motor is a stressed member on a CARC bike. You'll never get the bolts reliable torqued and keep tight, and will likely be buzzier. Balance TB's, (high and low speeds) proper valve adjust, proper plugs & gap, ensure no vacuum leaks and the motor should be butter smooth between 4&6k.Also a good idea to go over the bike. All fasteners, mounts including exhaust and suspension.Where/what conditions are you having issues?
Probably a bad idea, the engine is the lower portion of the frame. I have a 1200S,vibration is not much of a problem. Try heavier bar end weights if vibration is a bothering you.