First, lets agree on terminology. Moto Guzzi uses the word "transmission" to refer to the rear, final, bevel drive, and "gearbox" to refer to what most of us would call the transmission. Also, it is technically incorrect to call the final drive as a "differential", since it isn't one.
That said, the recommended change interval for the 6-sp gearbox oil is 1000 km and then 60,000 km, 120,000 km, etc. Why so long? First, the 6-sp box has an oil pump and an oil filter, and the 5-sp doesn't. The filter will remove bigger, damaging bits better than a non-filtered oil flow. Second, the 6-sp box doesn't have needle bearings like the 5-sp box does. These bearings are sensitive to tiny bits. Third, the recommended eni (AGIP) Rotra 75W-90 oil for the 6-sp box has an additional API rating (in addition to GL4 and GL5) that the oil for the 5-sp box doesn't, MT1. This spec is designed for extended change intervals, and also is supposed to lengthen the life of seals. This oil is used in heavy duty truck gearboxes that go 500,000 km or more between oil changes.
But, really, how often do you change the oil in manual car transmissions? I've driven many cars 150,000 miles or more, never had any gearbox problems, and have never changed the gearbox oil.