Never been a fan of gel set. They hold heat from the ride, the bike, and the sun, and can lead to the agony of monkey butt for me. As always, YMMV.
On the other hand beads allow air to circulate under your butt, help keep your butt out of the puddle that collects in the seat when riding in the rain, and they raise the effective set height providing a slightly longer reach to the pegs/ground. I like it all. Sometimes I'll throw a sheep skin over the beads for added comfort.
There's a solution for every ass, ya pick the one that best address the issue your want to resolve. The OEM seat on my '18 V7 Special is very comfy for me, have done 600-700+ miles days(solo) without issues. What a great little touring bike it is!
It's likely the Mrs. will need a few day to adapt and get comfy with long hours in the saddle no matter what you do. Give some thought to a Naproxen at breakfast and maybe one later in the day. I have neck and shoulder issues and find it to be a good solution for me. In my old age I sometimes gotta resort to old adage, ".......better living through chemistry". So sad. https://www.youtube.com/watch?v=tJtKkBYlHFw
You enjoy that trip, have fun, be safe.