The old Volvo OHV engines said 0.45mm of clearance, which is 1/64 or 18 thou. Presumably, they had "tamer" cam profiles, which would ease how the clearance was taken up before lifting of the valve began, but it is still a substantial clearance. Yet these engines would last "forever". Kawasaki, on the old Z1, listed clearance to be set between 0.05 and 0.20 mm IIRC, indicating that clearance is not critical in that engine. These engines also lasted a long time.
In my simple head, you would typically want more valve clearance with long duration cams in order to ensure that the valves stay close long enough. The cams on most Guzzis have quite short duration, though, so running the engine around the minimum recommended clearance should not hurt. Personally, I have stopped fretting about valve clearances; if the engine starts fine, idles fine, pulls well from low rpm AND does not clatter loudly, I do not bother to check the clearances. I do not run my engines hard, nor do we experience hot weathers, meaning the valve seats live a fairly sedate life. YMMV.